The purpose of this study is to investigate the effects of interactive boards applications supported by computer simulations on pre-service science teachers' self-regulated learning. Quasi-experimental research with pre test/post test control group design was used in the study. Pre-service science teachers in Siirt University, education faculty, science education department, constructed study group. Sections was randomly assigned experimental and control groups. In experimental group 32 pre-service science teachers (11 male 21 female), in control group 33 pre-service science teachers (13 male 20 female) were assigned to the groups. In total, 65 pre-service science teachers participated to the study. "Motivated strategies for learning questionnaire" was applied as the data collection tool. The questionnaire was translated into Turkish by Büyüköztürk and et.al. (2004). During the analysis in this respect, arithmetic averages, standard deviation, independent sampling t-test and analysis of covariance (ANCOVA) were used. The study compared the pre-test and post test scores of the science teacher candidates in the experiment and control group with SPSS 16.0 statistical package software.