The role of imitation in autism spectrum disorder (ASD) is controversial. Researchers have argued that deficient control of self- and other-related motor representations (self-other distinction) might explain imitation difficulties. In a recent EEG study, we showed that control of imitation relies on high-level as well as on low-level cognitive…

Children with autism spectrum disorder (ASD) sometimes have difficulties learning categories. Past computational work suggests that such deficits may result from atypical representations in cortical maps. Here we use neural networks to show that idiosyncratic transformations of inputs can result in the formation of feature maps that impair…

Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship…

Although resistance to change is a main feature of autism, the brain processes underlying this aspect of the disorder remain poorly understood. The aims of this study were to examine neural basis of auditory change-detection in children with autism spectrum disorders (ASD; N = 27) through electrophysiological patterns (MMN, P3a) and to test…

Results from functional imaging studies are often still interpreted using the classical architectonic brain maps of Brodmann and his successors. One obvious weakness in traditional, architectural mapping is the subjective nature of localizing borders between cortical areas by means of a purely visual, microscopical examination of histological…

Although some have argued that the type of language and cognitive defects shown by autistic children almost certainly reflects forebrain dysfunctions, current studies point to the possibility that some autistic children may have dysfunction of neural systems in the brainstem. (Author)

Many people with the diagnosis of Asperger syndrome (AS) show poorly developed skills in understanding emotional messages. The present study addressed discrimination of speech prosody in children with AS at neurophysiological level. Detection of affective prosody was investigated in one-word utterances as indexed by the N1 and the mismatch…

This review of the literature on the neuropsychology of autism identifies several consistent findings, such as: existence of neuropsychological impairments in a wide range of domains; large individual differences in certain neuropsychological domains; greater difficulty with tasks involving social information; possible association of the amygdala…

This study investigated personality and neurobehavioral differences between 16 children with Asperger's Disorder, 15 children with High-Functioning Autism (HFA), and 31 controls, all ranging in age from 5-17 years, M age = 10.7 years, SD = 3.0. Parents rated their children's behaviors on a 44-item autistic symptoms survey and on the 200-item…

The study investigated two neurophysiologic components of event-related brain potential during auditory and visual target detection tasks with 11 non-retarded autistic children, 9 retarded autistic children, and 16 normal subjects, aged 15-19. Results were consistent with the hypothesis that non-retarded autism involves abnormal attentional and…

This paper discusses language and communication deficits observed in autism within the framework of the "theory of mind" hypothesis, which posits that autistic individuals have profound difficulty interpreting a person's actions within a mentalistic framework. Placing language and communicative deficits within a theory of mind framework…

This paper explores the neural systems underlying social behaviors as they pertain to autism. It discusses major channels for transmission of social-emotional information, neural pathways subserving social behaviors, and social cognition in autism. A hypothesis of autism based on deviant development of the widely distributed neural system…