NotesFAQContact Us
Collection
Advanced
Search Tips
Showing all 6 results Save | Export
Peer reviewed Peer reviewed
Direct linkDirect link
Chez, Michael; Kile, Shawn; Lepage, Christopher; Parise, Carol; Benabides, Bobbie; Hankins, Andrea – Journal of Autism and Developmental Disorders, 2020
Prior studies have demonstrated successful irritability treatment using dopaminergic antagonists in autistic patients. The purpose of this pilot study was to assess the effect of dextromethorphan/quinidine (DM/Q) in autistic adults (18-60 years of age). This was a randomized, blinded, crossover, study of 14 patients randomized to DM/Q or a placebo…
Descriptors: Outcomes of Treatment, Randomized Controlled Trials, Pilot Projects, Drug Therapy
Peer reviewed Peer reviewed
Direct linkDirect link
Lewis, Alan S.; van Schalkwyk, Gerrit Ian; Lopez, Mayra Ortiz; Volkmar, Fred R.; Picciotto, Marina R.; Sukhodolsky, Denis G. – Journal of Autism and Developmental Disorders, 2018
Nicotinic acetylcholine receptors (nAChRs), particularly the a7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight…
Descriptors: Aggression, Adults, Stimulants, Pervasive Developmental Disorders
Peer reviewed Peer reviewed
Direct linkDirect link
Merineau-Cote, J.; Morin, D. – Journal of Intellectual Disability Research, 2013
Background: Some individuals with intellectual disabilities (IDs) exhibit aggressive behaviour directed towards themselves, others or the environment. Displaying aggressive behaviour is associated with a number of negative consequences such as the exposure to restrictive interventions. This study aims to identify personal and environmental factors…
Descriptors: Mental Retardation, Adults, Aggression, Behavior Problems
Peer reviewed Peer reviewed
Direct linkDirect link
Dunlap, Glen; Carr, Edward G.; Horner, Robert H.; Koegel, Robert L.; Sailor, Wayne; Clarke, Shelley; Koegel, Lynn Kern; Albin, Richard W.; Vaughn, Bobbie J.; McLaughlin, Darlene Magito; James, Kim Mullen; Todd, Anne W.; Newton, J. Stephen; Lucyshyn, Joseph; Griggs, Peter; Bohanon, Hank; Choi, Jeong Hoon; Vismara, Laurie; Minjarez, Mendy Boettcher; Buschbacher, Pamelazita; Fox, Lise – Behavioral Disorders, 2010
A major goal of positive behavior support (PBS) is to produce broad-based, long-term improvements in adaptive behavior; however, the empirical base, at present, is mainly composed of relatively short-term studies carried out in circumscribed contexts. Therefore, a need exists for reliable data that can inform the field regarding the comprehensive…
Descriptors: Intervention, Quality of Life, Behavior Modification, Rating Scales
Peer reviewed Peer reviewed
Direct linkDirect link
Hellings, Jessica A.; Zarcone, Jennifer R.; Reese, R. Matthew; Valdovinos, Maria G.; Marquis, Janet G.; Fleming, Kandace K.; Schroeder, Stephen R. – Journal of Autism and Developmental Disorders, 2006
Risperidone has shown safety and efficacy for aggressive and destructive behaviors in short-term studies. This longer-duration study includes a broad sample. Forty subjects, aged 8-56 years (mean=22), all with mental retardation and 36 with autism spectrum disorders participated in this 22-week crossover study, with 24 weeks of open maintenance…
Descriptors: Drug Therapy, Mental Retardation, Pervasive Developmental Disorders, Children
Peer reviewed Peer reviewed
Rojahn, Johannes; Aman, Michael G.; Matson, Johnny L.; Mayville, Erik – Research in Developmental Disabilities, 2003
A study compared the Aberrant Behavior Checklist (ABC) and the Behavior Problems Inventory (BPI) for assessing the maladaptive behavior of 226 adults, mostly with severe or profound mental retardation. Individuals with elevated BPI scores generally had higher ABC scores, however, the extent of covariation differed across subscales. (Contains…
Descriptors: Adult Education, Adults, Aggression, Behavior Problems