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Wiggins, Lisa D.; Reynolds, Ann; Rice, Catherine E.; Moody, Eric J.; Bernal, Pilar; Blaskey, Lisa; Rosenberg, Steven A.; Lee, Li-Ching; Levy, Susan E. – Journal of Autism and Developmental Disorders, 2015
The Study to Explore Early Development (SEED) is a multi-site case-control study designed to explore the relationship between autism spectrum disorder (ASD) phenotypes and etiologies. The goals of this paper are to (1) describe the SEED algorithm that uses the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule…
Descriptors: Autism, Pervasive Developmental Disorders, Case Studies, Correlation
Klusek, Jessica; Losh, Molly; Martin, Gary E. – Autism: The International Journal of Research and Practice, 2014
While there is a strong sex bias in the presentation of autism, it is unknown whether this bias is also present in subclinical manifestations of autism among relatives, or the broad autism phenotype. This study examined this question and investigated patterns of co-occurrence of broad autism phenotype traits within families of individuals with…
Descriptors: Gender Differences, Genetic Disorders, Genetics, Pragmatics
Connolly, John J.; Glessner, Joseph T.; Hakonarson, Hakon – Child Development, 2013
Efforts to understand the causes of autism spectrum disorders (ASDs) have been hampered by genetic complexity and heterogeneity among individuals. One strategy for reducing complexity is to target endophenotypes, simpler biologically based measures that may involve fewer genes and constitute a more homogenous sample. A genome-wide association…
Descriptors: Autism, Pervasive Developmental Disorders, Genetics, Genetic Disorders
Wolff, Jason J.; Bodfish, James W.; Hazlett, Heather C.; Lightbody, Amy A.; Reiss, Allan L.; Piven, Joseph – Journal of the American Academy of Child & Adolescent Psychiatry, 2012
Objective: How does the behavioral expression of autism in fragile X syndrome (FXS + Aut) compare with idiopathic autism (iAut)? Although social impairments and restricted, repetitive behaviors are common to these variants of autism, closer examination of these symptom domains may reveal meaningful similarities and differences. To this end, the…
Descriptors: Genetic Disorders, Mental Retardation, Congenital Impairments, Autism
Moss, Jo; Howlin, Patricia; Magiati, Iliana; Oliver, Chris – Journal of Child Psychology and Psychiatry, 2012
Background: The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in Cornelia de Lange syndrome (CdLS). However, the profile and developmental trajectories of these ASD characteristics are potentially different to those observed in individuals with idiopathic ASD. In this study we examine the ASD profile in CdLS in…
Descriptors: Autism, Pervasive Developmental Disorders, Genetic Disorders, Mental Retardation
Szatmari, Peter; Georgiades, Stelios; Bryson, Susan; Zwaigenbaum, Lonnie; Roberts, Wendy; Mahoney, William; Goldberg, Jeremy; Tuff, Lawrence – Journal of Child Psychology and Psychiatry, 2006
Background: The Restricted, Repetitive Behaviours and Interests (RRBIs) are represented in the DSM-IV and measured by the Autism Diagnostic Interview-Revised (ADI-R) as one of the three homogeneous symptom categories of Pervasive Developmental Disorders. Although this conceptualisation is well accepted in the field, the grouping of symptoms is…
Descriptors: Evidence, Medical Evaluation, Autism, Interests