The present study aimed to examine risk and protective factors of African American students at a historically Black university in the southeastern region of the U.S. A total of 326 students participated in a cross-sectional self-report survey as to scores of the Internet Addiction Test, depression, resilience, and socio-demographic information. A stepwise multiple-regression analysis revealed that depression and being a freshman, respectively, were predictors of internet addiction. Chi-square tests showed that there was significant positive association between internet addiction and depression, while internet addiction was negatively associated with resilience. These findings provide useful information for developing culturally tailored interventions of internet addiction for African American college students especially who are depressed and not resilient in their first year.