Undergraduate college-going is now undertaken well into adulthood, but knowledge about what leads individuals to enroll derives nearly entirely from the study of the "traditionally-aged". I examine whether and how predictors of enrollment vary as individuals progress through the life-course using nationally representative data from the United States, following a cohort from ages 18-45. Measures of social background and academic preparation are only weakly predictive beyond age 24, while the effects of gender are largest after age 35. Marriage appears to be a barrier to enrollment among males and females, but only until age 25. Involuntary job loss spurs college-going most strongly among those aged 35 or older, and particularly among women. Among those over age 25, marital dissolution predicts enrollment positively among females but negatively among males.