The purpose of the current study was to investigate the evidence of validity of the Skill Scale scores on the Campbell Interest and Skill Survey (CISS). In a sample of 221 college students, analyses between the CISS Skill Scale scores and the CISS Interest Scale, the Strong Interest Inventory, and self-reported MAEQ abilities scores were conducted. Results provided evidence of convergent and discriminate validity of the Skill Scale scores. Furthermore, Skill Scale scores were found to be predictive of declared college major above chance levels. Conclusions from the results support the use of the CISS Skill Scales in counseling settings. Further investigation of the content being measured by the Skill Scales and their use in career interventions is recommended.