This study investigated the effects of cognitive strategy instruction on the mathematical problem solving of three adolescents with spina bifida. Conditions of the multiple-baseline across-individuals design included baseline, two levels of treatment, posttesting, and maintenance. Treatment 1 focused on one-step math problems, and Treatment 2 focused on two-step problems. All students substantially improved as measured by performance on criterion tests of math problem solving. Discussion centers on the need for intervention studies with students with spina bifida that specifically address their unique characteristics and the adaptations and accommodations that benefit these students. (Contains 1 table and 2 figures.)