This guidance centers around the users of artificial intelligence (AI) in various roles throughout West Virginia PK-12 schools. It is designed to assist individuals such as superintendents, district staff, educators, and support staff in the appropriate and effective use of AI, particularly generative AI technologies, within West Virginia schools. Its focus includes classroom instruction, school administration, and the broader scope of district operations. While recognizing the significant opportunities AI presents for enhancing educational experiences in West Virginia, this document also addresses the need for careful oversight to minimize risk and ensure responsible use. It is fundamental that realistic risks are assessed and addressed in order to protect students and staff. Predictable risks include over-reliance on AI technologies, challenges to independent and creative thinking, reduced social interactions, privacy and safety issues, furthering of digital divides, as well as plagiarism and cheating. It is imperative that West Virginia schools and districts demonstrate proactive preparedness to answer these challenges.