Based on the premise that educators can make a significant difference in children's lives, this preschool and kindergarten substance abuse prevention curriculum guide informs teachers about basic prevention concepts and provides a plan for integrating these concepts within the context of an early childhood education program. The curriculum is designed around four prevention theme units of self-awareness, decision-making, healthy living, and communication. Each theme is used as the nucleus of activities included in the instructional areas of: (1) language development; (2) social living; (3) creative expression; and (4) mathematics, science, and health. This booklet contains four specific class activities, each representing an instructional area, in each of the theme units. A list of related children's books is provided with most activity sheets, and drawings are included. (JHP)