With climate change continuing to be the biggest global threat, this paper argues that universities and colleges should take a leading role in putting the world on a more sustainable footing. Making use of the latest research and powerful case studies, the author makes a series of recommendations for students, staff and policymakers that would deliver a new approach, from changes to day-to-day operations to the core educational mission and civic role of the university. These recommendations include: (1) Redesigning the day-to-day operations of universities and colleges; (2) Reinvigorating the civic role of institutions; (3) Reshaping the knowledge structures of the university; and (4) Refocusing the educational mission of the institution to support students.