There is no formal mandate for or tradition of inter-sectoral collaboration between community colleges and universities in Ontario. Following a regulatory change introduced by the College of Nurses of Ontario in 1998, all Registered Nurse educational preparation was restructured to the baccalaureate degree level through province-wide adoption of a college-university collaborative nursing program model. Despite complex sectoral differences in organizational culture, mandates, and governance structures, this program model was promoted by nursing educators and policy-makers as an innovative approach to utilizing the post-secondary system's existing nursing education infrastructure and resources. This paper provides an overview of the introduction of Ontario's collaborative baccalaureate nursing programs and discusses some of challenges associated with implementing and maintaining such programs. (Contains 1 table.)