This study reviewed the literature on the clinical features of Asperger Syndrome, a form of autism, looking for evidence that a tendency toward violence is common in individuals with the syndrome. Although many studies were excluded on the basis of inadequate data, findings of remaining studies did not support the speculation that violence is…

Interviews with parents of 30 school-age girls with fragile X syndrome (fraX) and 31 age- and IQ-matched controls concerning autistic behaviors found that girls with fraX had significantly more autistic behaviors than controls, but incidence of autistic behaviors was not correlated with IQ. Anxiety and posterior cerebellar area measures were also…

The study compared the attention-directing behaviors of 15 autistic children, 14 children with developmental language delay, and 13 young normal children. Although the autistic children's behavior was most unlike that of the other groups, autistic children did not produce more attention-directing behavior when a high degree of adult direction was…

Available information is reviewed on defining features and diagnostic issues related to autism and related developmental disorders. Controversies over both the boundaries and the heterogeneity within the autism syndrome are evaluated. Diagnostic rating instruments for expediting systematic sample selection are critiqued. (Author/DB)

The follow-up study examined 16 schizo-affective children after a mean of 16 years. In comparison to purely schizophrenic controls, subjects showed an increased incidence of affective psychoses, suicide in the ancestry, and more pre-morbidly well-adjusted personalities. The schizo-affective psychoses had mainly an acute-recurrent character.…

The effectiveness of fenfluramine with hyperserotonergic autistic individuals (n=28 and ages 6-30) was evaluated. Evaluation of videotape recordings of individual behaviors suggested that fenfluramine failed to increase communicative behaviors or decrease stereotypic behaviors and inappropriate behaviors although a serotonergic effect was found in…

Evaluation of the cognitive, behavioral, and adaptive functioning of 12 retarded men with fragile X syndrome indicated that fragile X men were largely indistinguishable from comparison groups. They were, however, significantly more likely to have achieved levels of adaptive functioning commensurate with their intellectual abilities. (Author/DB)

This case study of two young males (ages 3 and 5) with autism who have preoccupations with feminine activities and objects addresses the establishment of gender identity in children with autism and the need for further study of the complex interplay of environmental and neurobiologic factors affecting gender identity and preoccupations in autism.…

This study examined Autism Diagnostic Interviews Revised (ADI-R) data for 69 autistic subjects from multiplex (MP) families (with more than one autistic member) and 88 autistic subjects from singleton (SP) families (with only one autistic member). Multivariate analysis revealed no differences between verbal or nonverbal MP and SP groups for ADI-R…

This study investigated demographic and phenomenological characteristics of obsessive compulsive disorder (OCD) in nine adults with Down syndrome (DS), and possible effects on adaptive behavior. Results suggest OCD is more common in the DS population than the non-DS population. Ordering and tidiness was the most common form of OCD found, and…

This case study of a toddler with autism whose parents had videotaped her development from birth showed that the child's behavior and development were essentially normal for the first year but that she then became withdrawn in only a few months. It is suggested that early communicative screening tests might have identified the child's earliest…

Two firsthand accounts from verbal high-functioning individuals with autism (a 27-year-old man and a 13-year-old boy and his parents) are presented. Five salient themes are identified: sensory processing, memory, stereotypical behaviors, social interaction, and empathy. Multichanneled sensory processing appeared in both subjects as did a detailed…

This study examined the effectiveness of the Behavior Summarized Evaluation to discriminate 58 autistic from 58 nonautistic mentally retarded children. The measure clearly separated the two samples with between-group differences highest on four items indicating the most particular pattern in autistic children was the association of autistic…

A cluster analytic study was conducted to derive behaviorally homogeneous subtypes of pervasive developmental disorders (PDD) based on a range of behavioral symptoms that characterize autism. Analysis of data on 34 children with PDD, 27 of whom met criteria for autism, indicated 4 distinct groups differing on independent measures of social,…

Comparison of caregiver behaviors of children with either autism, developmental delay, or typical development found no difference between groups in caregiver synchronization with the child's focus of attention. Also, caregivers of children with autism who showed higher levels of synchronization during initial play interactions led to superior…