Enzymes are nature's catalysts, mediating chemical processes in living systems. The study of enzyme function and mechanism includes defining the maximum catalytic rate and affinity for substrate/s (among other factors), referred to as enzyme kinetics. Enzyme kinetics is a staple of biochemistry curricula and other disciplines, from molecular and…

Children learn arithmetic procedures by rote, rather than by constructing them with an understanding of numbers. Rote learning produces lack of flexibility, nonsensical errors, and other difficulties. Proposed is a theory of conceptual understanding and its role in learning and executing arithmetic procedures. The basic hypothesis is that…

Proposes a theory of cognitive processes in doing and learning place value arithmetic. Discusses a computer model that simulates the learning of multicolumn subtraction under one-on-one tutoring to measure the relative difficulty of two methods of subtraction. The model predicts that regrouping is more difficult to learn than an alternative…

In this article, the author discusses the use in policy analysis of models that incorporate uncertainty. He believes that all models should consider incorporating uncertainty, but that at the same time it is important to understand that sampling variability is not usually the dominant driver of uncertainty in policy analyses. He also argues that…