Enzymes are nature's catalysts, mediating chemical processes in living systems. The study of enzyme function and mechanism includes defining the maximum catalytic rate and affinity for substrate/s (among other factors), referred to as enzyme kinetics. Enzyme kinetics is a staple of biochemistry curricula and other disciplines, from molecular and…

In this essay, the author tries to look forward into the 21st century to divine three things: (i) What skills will researchers in the future need to solve the most pressing problems? (ii) What are some of the most likely candidates to be those problems? and (iii) What are some current areas of research that seem mined out and should not distract…

Four empirical laws of bibliometrics--anomalous number, Lotka's, Zipf's, and Bradford's--together with Laplace's "law of succession" and de Solla Price's cumulative advantage distribution are shown to be almost identical. A simple model shows that the frequency forms conform with inverse square law over appropriate interval. (Fifteen…

A method for assessing scientific performance based on relationships displayed numerically in published documents is proposed and illustrated using published documents in pediatric oncology for the period 1979-1982. Contributions of a major clinical investigations group, the Childrens Cancer Study Group, are analyzed. Twenty-nine references are…

Describes an expected precision (EP) measure designed to predict document retrieval performance. Highlights include decision theoretic models; precision and recall as measures of system performance; EP graphs; relevance feedback; and computing the retrieval status value of a document for two models, the Binary Independent Model and the Two Poisson…

Frequency-of-circulation distributions from 16 United Kingdom libraries participating in initial period of operation of the Public Lending Right are discussed. Differences between the libraries are highlighted, and, for each, the adequacy of various refinements of the simplest model (geometric distribution, negative binomial distribution, or mixed…

Examines the relationship that might exist between knowledge structure and learning and teaching styles. Discussion includes the Psycho-Epistemic Profile, which measures the process of knowing, and a study of relationships between teachers' and students' psycho-epistemic styles and preferred subject matter, and differences between psycho-epistemic…

This paper is a preliminary inquiry by a non-mathematician into graphic methods of sequential planning and ways in which hierarchical analysis and tree structures can be helpful in developing interest in the use of mathematical modeling in the search for creative solutions to real-life problems. Highlights include a discussion of hierarchical…

The Hepatitis Knowledge Base (text of prototype information system) was used for modifying and testing "A Navigator of Natural Language Organized (Textual) Data" (ANNOD), a retrieval system which combines probabilistic, linguistic, and empirical means to rank individual paragraphs of full text for similarity to natural language queries…

Discusses current use of psychological theory in software science and reviews recent developments in cognitive psychology relevant to programing (human information processing, expert-novice differences). Critique of Maurice Halstead's model of cognitive aspects of programing and a structured data flow perspective (control flow and data flow…

Defines relationship between user profile and user query in terms of relationship between clusters of documents retrieved by each, and explores the expression of cluster similarity and cluster overlap as linear functions of similarity existing between original pairs of profiles and queries, given the desired retrieval threshold. (23 references)…

Presents a diagram for figuring the value of time into an individual's labor-supply decisions and the time intensiveness of the individual's consumption patterns. Seeks to make the integration of differing time values with leisure income choices more understandable for students. (DK)

Utilizing 11 years of University of Saskatchewan circulation transactions, it is shown that P. M. Morse's Markov model of book use fits approximately 99 percent of data for whole collection and for three subject areas; contrary to his assumptions, one of the model's parameters is time dependent. Thirteen references are included. (EJS)

MINDS (Multiple Intelligent Node Document Servers) is a distributed system of knowledge-based query engines for efficiently retrieving multimedia documents in an office environment of distributed workstations. By learning document distribution patterns and user interests and preferences during system usage, it customizes document retrievals for…

Reports algorithm for calculation of term discrimination values that is sufficiently fast in operation to permit use of exact values. Evidence is presented to show that relationship between term discrimination and term frequency is crucially dependent upon type of inter-document similarity measure used for calculation of discrimination values. (13…