Measurement of clinically significant change is critical for rehabilitation research because it can enhance the credibility of rehabilitation efforts and guide evidence-based practices. The practical appeal of clinically significant change is that it can bridge research and clinical practice by focusing on individual rather than group differences. In response to current challenges in rehabilitation outcome measurement, the authors describe methods and strategies for the analysis of clinically significant change. The complementary approaches of reliable change index scores as proposed by Jacobson and Truax (1991) and regression-based z scores as proposed by McSweeney, Naugle, Chelune, and Luders (1993) are highlighted. The article concludes with a case example and discussion of implications for future directions in rehabilitation research.