Number talks are increasingly used in general education mathematics classes to engage students. Yet despite the potential benefits, number talks are given limited attention for students with high-incidence disabilities in special education settings. This article presents special education teachers with both the why and, more important, the how for implementing number talks to support students with high-incidence disabilities in special education settings. Specifically, the authors address how number talks can serve as both a formative assessment and an intervention for fluency and activating students' background knowledge to be successful in general education settings. The article also provides suggestions for implementing number talks with fidelity and flexibility (e.g., use of manipulatives, pictorial representations, and teacher explicit instruction of numerical strategies).