Many high schools struggle with developing an efficient system to effectively deliver college and career readiness (CCR) instruction and experiences to all students. The implementation of Positive Behavioral Interventions and Supports (PBIS) in high schools offers an opportunity to consider how the PBIS framework can support CCR for all students. The purpose of this brief is to provide guidance and concrete examples to school personnel of how schools can leverage an existing PBIS framework to support CCR efficiently and effectively.