In some instances, intentionally or not, study designs are such that there is clustering in one group but not in the other. This paper describes methods for computing effect size estimates and their variances when there is clustering in only one group and the analysis has not taken that clustering into account. The authors provide the effect size…

A common mistake in analysis of cluster randomized trials is to ignore the effect of clustering and analyze the data as if each treatment group were a simple random sample. This typically leads to an overstatement of the precision of results and anticonservative conclusions about precision and statistical significance of treatment effects. This…