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Direct linkBaker, Kathryn D.; McNally, Gavan P.; Richardson, Rick – Learning & Memory, 2012
The NMDA receptor partial agonist d-cycloserine (DCS) enhances the extinction of learned fear in rats and exposure therapy in humans with anxiety disorders. Despite these benefits, little is known about the mechanisms by which DCS promotes the loss of fear. The present study examined whether DCS augments extinction retention (1) through reductions…
Descriptors: Anxiety Disorders, Context Effect, Anxiety, Fear
Kim, Jee Hyun; Richardson, Rick – Learning & Memory, 2009
Several recent studies report that neurotransmitters that are critically involved in extinction in adult rats are not important for extinction in young rats. Specifically, pretest injection of the [gamma]-aminobutryic acid (GABA) receptor inverse agonist FG7142 has no effect on extinction in postnatal day (P)17 rats, although it reverses…
Descriptors: Animals, Fear, Pretests Posttests, Experiments
