In recent years, the science of developing and implementing interventions addressing school-related risk factors has produced many advances. This article addresses the promise of a cross-disciplinary practice approach known as motivational interviewing in school settings. Specifically, the supporting evidence as well as the process and principles of motivational interviewing are described for those unfamiliar with motivational interviewing nomenclature. A description of recent school-based innovations using the principles of motivational interviewing is then provided. Next, some potential applications for applying the motivational interviewing approach in educational settings to enhance the adoption, development, and implementation of effective school-based interventions designed to promote academic achievement and prevent or ameliorate challenging behavior are proposed. The article concludes with a discussion of future directions of motivational interviewing approaches within the context of school mental health.