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Relationship between Early Social-Emotional Behavior and Autism Spectrum Disorder: A High-Risk Sibling Study
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Raza, Sarah; Sacrey, Lori-Ann R.; Zwaigenbaum, Lonnie; Bryson, Susan; Brian, Jessica; Smith, Isabel M.; Roberts, Wendy; Szatmari, Peter; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy – Journal of Autism and Developmental Disorders, 2020
Social-emotional behavior in autism spectrum disorder (ASD) was examined among high-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers. Caregivers completed the Infant-Toddler Social Emotional Assessment (ITSEA) at 18 months, and blind diagnostic assessment for ASD was conducted at 36 months.…
Descriptors: Autism, Pervasive Developmental Disorders, Genetics, Clinical Diagnosis
Naturalistic Language Recordings Reveal "Hypervocal" Infants at High Familial Risk for Autism
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Swanson, Meghan R.; Shen, Mark D.; Wolff, Jason J.; Boyd, Brian; Clements, Mark; Rehg, James; Elison, Jed T.; Paterson, Sarah; Parish-Morris, Julia; Chappell, J. Chad; Hazlett, Heather C.; Emerson, Robert W.; Botteron, Kelly; Pandey, Juhi; Schultz, Robert T.; Dager, Stephen R.; Zwaigenbaum, Lonnie; Estes, Annette M.; Piven, Joseph – Child Development, 2018
Children's early language environments are related to later development. Little is known about this association in siblings of children with autism spectrum disorder (ASD), who often experience language delays or have ASD. Fifty-nine 9-month-old infants at high or low familial risk for ASD contributed full-day in-home language recordings.…
Descriptors: Infants, Autism, Pervasive Developmental Disorders, Environmental Influences
Potential Risk Factors for the Development of Self-Injurious Behavior among Infants at Risk for Autism Spectrum Disorder
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Dimian, Adele F.; Botteron, Kelly N.; Dager, Stephen R.; Elison, Jed T.; Estes, Annette M.; Pruett, John R., Jr.; Schultz, Robert T.; Zwaigenbaum, Lonnie; Piven, Joseph; Wolff, Jason J. – Journal of Autism and Developmental Disorders, 2017
Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose…
Descriptors: Risk, Self Destructive Behavior, Autism, Pervasive Developmental Disorders
Structure of the Autism Symptom Phenotype: A Proposed Multidimensional Model
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Georgiades, Stelios; Szatmari, Peter; Zwaigenbaum, Lonnie; Duku, Eric; Bryson, Susan; Roberts, Wendy; Goldberg, Jeremy; Mahoney, William – Journal of the American Academy of Child and Adolescent Psychiatry, 2007
Background: The main objective of this study was to develop a comprehensive, empirical model that would allow the reorganization of the structure of the pervasive developmental disorder symptom phenotype through factor analysis into more homogeneous dimensions. Method: The sample consisted of 209 children with pervasive developmental disorder…
Descriptors: Siblings, Factor Analysis, Correlation, Autism
Conducting Genetic Epidemiology Studies of Autism Spectrum Disorders: Issues in Matching
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Szatmari, Peter; Zwaigenbaum, Lonnie; Bryson, Susan – Journal of Autism and Developmental Disorders, 2004
The objective of this review is to clarify the role of matching in family genetic studies of autism as a way of defining endophenotypes for linkage analysis. The concept of a confounding variable is reviewed and the importance of considering these in family studies of three endophenotypes in autism are considered: cognitive/language impairments,…
Descriptors: Genetics, Epidemiology, Siblings, Family (Sociological Unit)