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The Role of Circadian Rhythms and Sleep in the Aetiology of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: New Evidence from Bidirectional Two-Sample Mendelian Randomization Analysis
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Xiaotian Dai; Gareth J. Williams; John A. Groeger; Gary Jones; Keeley Brookes; Wei Zhou; Jing Hua; Wenchong Du – Autism: The International Journal of Research and Practice, 2025
Increasing evidence highlights the role of disrupted circadian rhythms in the neural dysfunctions and sleep disturbances observed in autism spectrum disorder and attention-deficit/hyperactivity disorder. However, the causality and directionality of these associations remain unclear. In this study, we employed a bidirectional two-sample Mendelian…
Descriptors: Foreign Countries, Autism Spectrum Disorders, Attention Deficit Hyperactivity Disorder, Sleep
Echocardiographic Evaluation of the Effect of Long-Term Methylphenidate Use on Cardiovascular Functions
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Çagatay Tunca; Ibrahim Hakan Güllü; Saadet Demirtas Inci; Kamuran Kalkan; Ruken Demirkol Tunca; Aysegül Efe; Ayse Nur Özkaya Ibis; Alperen Tas; Mehmet Taha Özkan; Veysel Ozan Tanik; Orçun Ortaköylü; Nail Burak Özbeyaz – Journal of Attention Disorders, 2025
Objective: ADHD is one of the most common neurodevelopmental disorders, seen in children and adolescents, and is often treated with various pharmacological agents, especially methylphenidate. There are differing opinions in the literature regarding the cardiovascular safety of long-term methylphenidate use. Studies suggest that the drug may…
Descriptors: Late Adolescents, Young Adults, Attention Deficit Hyperactivity Disorder, Heart Disorders
Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years
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Irene Campos-Sánchez; Eva María Navarrete-Muñoz; Dries S. Martens; Isolina Riaño-Galán; Aitana Lertxundi; Sabrina Llop; Mónica Guxens; Cristina Rodríguez-Dehli; Nerea Lertxundi; Raquel Soler-Blasco; Martine Vrijheid; Tim S. Nawrot; John Wright; Tiffany C. Yang; Rosie McEachan; Kristine Bjerve Gützkow; Vaia Lida Chatzi; Marina Vafeiadi; Mariza Kampouri; Regina Grazuleviciene; Sandra Andrusaityte; Johanna Lepeule; Desirée Valera-Gran – Journal of Attention Disorders, 2025
Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years. Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a…
Descriptors: Foreign Countries, Genetic Disorders, Attention Deficit Hyperactivity Disorder, Mothers