Background: Many children in the United States are victims of bullying; many of the victimized retaliate, aggressively bullying those who have bullied them. Objective: Applying the multiple disadvantage model, this U.S.-based secondary study of data describing bullied children's own perpetration of bullying examined this behavior's relationship to 5 kinds of factors: social disorganization, social structural, social relationship, mental health, and access to care. Method: This secondary data analysis involved a sample of 11,270 bullied children extracted from the 2021 National Survey of Children's Health. Results: Results of logistic regression indicate that among the sample, likelihood of perpetrating bullying was associated in positive direction with residence in a rundown neighborhood, experiencing racial discrimination, child age 6-10 years, caregiver education level, caregiver with reported difficulty parenting, child behavioral/conduct problem(s), and family member substance-use problem. Likelihood of perpetrating bullying was associated in negative direction with being a girl, having Asian ethnicity, older caregiver, family cohesiveness, and child depression. Conclusions: The present study's findings support the multiple disadvantage model that four types of socioeconomic disadvantage--social disorganization, social structural factors, social relationships, and mental health--are related to bullied children's bullying perpetration.