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Direct linkRebecca M. Pollak; Michael Mortillo; Melissa M. Murphy; Jennifer G. Mulle – Journal of Autism and Developmental Disorders, 2025
3q29 deletion syndrome (3q29del) is associated with a significantly increased risk for neurodevelopmental and neuropsychiatric disorders. However, the full spectrum of behavioral phenotypes associated with 3q29del is still evolving. Individuals with 3q29del (n = 96, 60.42% male) or their guardian completed the Achenbach Child or Adult Behavior…
Descriptors: Genetic Disorders, Neurodevelopmental Disorders, Behavior Disorders, Symptoms (Individual Disorders)
Daniel A. Geller; Mia Grossman – Journal of Attention Disorders, 2024
Objective: To use a family genetic study to evaluate familial risk of obsessive compulsive disorder (OCD) and common comorbid illnesses in first-degree relatives of pediatric-onset probands with primary OCD. Method: One hundred and thirty youth with OCD and their 133 siblings and 241 parents and 49 pediatric controls were directly evaluated along…
Descriptors: Heredity, Anxiety Disorders, Comorbidity, Child Health
Gow, Joan-Beth; Carpino, Lisa A. – Journal of College Science Teaching, 2018
Anorexia nervosa is a complex behavioral disorder with the highest risk of death of any psychological disorder. Between 15% and 20% of those suffering from anorexia die from complications that are attributed either directly or indirectly to self-starvation. Heritability for anorexia is around 0.5, meaning about 50% of the risk for anorexia is…
Descriptors: Case Studies, Interdisciplinary Approach, Behavior Disorders, Eating Disorders
Zuhal Koc Apaydin; Meryem Kasak; Ozlem Karakaya; Hakan Ogutlu; Mustafa Ugurlu; Fiona McNicholas – Journal of Attention Disorders, 2025
Objective: This study aimed to investigate the relationship between Cognitive Disengagement Syndrome (CDS) symptoms in children/adolescents and their parents within the Turkish population, examining the association with co-occurring ADHD symptoms, peer/social relationships, and total difficulties. Method: The study included 229 parents aged 18 to…
Descriptors: Children, Adolescents, Parents, Symptoms (Individual Disorders)
Royston, R.; Oliver, C.; Howlin, P.; Dosse, A.; Armitage, P.; Moss, J.; Waite, J. – Journal of Autism and Developmental Disorders, 2020
Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader-Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12-57 years);…
Descriptors: Psychopathology, Genetic Disorders, Correlation, Predictor Variables
Neo, Wei Siong; Tonnsen, Bridgette L. – Journal of Autism and Developmental Disorders, 2019
Children with neurogenetic syndromes (NGS) experience comorbid challenging behaviors and psychopathology. We examined challenging behaviors in 86 toddlers and preschoolers across three NGS [Angelman syndrome (AS), Prader--Willi syndrome (PWS), and Williams syndrome (WS)] and 43 low-risk controls (LRC), using the Child Behavior Checklist for Ages…
Descriptors: Autism, Pervasive Developmental Disorders, Behavior Disorders, Psychopathology
Thomason, Molly Mishler; McCarthy, John; Goin-Kochel, Robin P.; Dowell, Lauren R.; Schaaf, Christian P.; Berry, Leandra N. – Journal of Autism and Developmental Disorders, 2020
Truncating variants of the "MAGEL2" gene, one of the protein-coding genes within the Prader-Willi syndrome (PWS) critical region on chromosome 15q11, cause Schaaf-Yang syndrome (SYS)--a neurodevelopmental disorder that shares several clinical features with PWS. The current study sought to characterize the neurobehavioral phenotype of SYS…
Descriptors: Genetic Disorders, Neurological Impairments, Developmental Disabilities, Cognitive Ability
Van Wert, Hannah; McCabe, Paul C. – Communique, 2022
Conduct disorder (CD) is a pattern of repeated aggression toward others, disregard for the rights of others, and behaviors that violate major social norms at home, in school, and even in society at large (American Psychiatric Association [APA], 2013). Falling under the umbrella of "conduct problems" along with oppositional defiant…
Descriptors: Behavior Disorders, Females, Aggression, Clinical Diagnosis
Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna – Journal of Autism and Developmental Disorders, 2021
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD)…
Descriptors: Genetics, Autism, Pervasive Developmental Disorders, Biochemistry
Crawford, Hayley; Waite, Jane; Oliver, Chris – Journal of Autism and Developmental Disorders, 2017
Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous aetiology. In this study, we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for…
Descriptors: Anxiety Disorders, Intellectual Disability, Symptoms (Individual Disorders), Scores
Baptista, Joana; Sampaio, Adriana; Fachada, Inês; Osório, Ana; Mesquita, Ana R.; Garayzabal, Elena; Duque, Frederico; Oliveira, Guiomar; Soares, Isabel – Journal of Autism and Developmental Disorders, 2019
This study compared maternal responsiveness to children with two neurodevelopmental disorders sharing different but, in some cases, overlapping social phenotypes--Williams syndrome (WS) and autism spectrum disorder (ASD)--and explored the relations between maternal responsiveness and child emotional/behavioural problems (EBP). The sample included…
Descriptors: Mothers, Mother Attitudes, Child Rearing, Preschool Children
Bakken, Trine Lise; Hoidal, Siv Helene – International Journal of Developmental Disabilities, 2019
Background: Mental health services for patients intellectual disabilities (ID) and additional mental illnesses are only sparsely studied. Objective: The objective was to describe a representative sample of patients with ID in a specialized psychiatric department. Methods: Data were collected from case files in a 7-year period. Of 143 invited…
Descriptors: Patients, Psychiatric Hospitals, Behavior Disorders, Posttraumatic Stress Disorder
Silberg, Judy L.; Maes, Hermine; Eaves, Lindon J. – Journal of Child Psychology and Psychiatry, 2012
Background: A critical issue in devising effective interventions for the treatment of children's behavioral and emotional problems identifying genuine family environmental factors that place children at risk. In most twin and family studies, environmental factors are confounded with both direct genetic risk from parents and the indirect effect of…
Descriptors: Emotional Problems, Twins, Parent Influence, Hyperactivity
Wolfenden, C.; Wittkowski, A.; Hare, D. J. – Journal of Autism and Developmental Disorders, 2017
The prevalence of autism spectrum disorder (ASD) in many genetic disorders is well documented but not as yet in Mucopolysaccharidosis type III (MPS III). MPS III is a recessively inherited metabolic disorder and evidence suggests that symptoms of ASD present in MPS III. This systematic review examined the extant literature on the symptoms of ASD…
Descriptors: Autism, Pervasive Developmental Disorders, Genetic Disorders, Symptoms (Individual Disorders)
Beaudet, Arthur L. – Child Development, 2013
Chromosomal microarray analysis (CMA) has emerged as a powerful new tool to identify genomic abnormalities associated with a wide range of developmental disabilities including congenital malformations, cognitive impairment, and behavioral abnormalities. CMA includes array comparative genomic hybridization (CGH) and single nucleotide polymorphism…
Descriptors: Genetics, Genetic Disorders, Developmental Disabilities, Identification
