Several studies have reported conflicting results when assessing associations between stress and repetitive behaviors in individuals with autism spectrum disorder (ASD). Some factors that may have caused these discrepant results include the monitoring of a single broad category for repetitive behaviors, the heterogeneity of the participants, and…

Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, the etiology of which has not been clearly determined yet. There is increasing evidence that synaptic and dendritic changes are involved in the etiology of ASD. The aim of this study is to determine whether serum Thrombospondin-1 and Thrombospondin-2 differ between ASD…

To better understand the role of neuroendocrinological regulation in adolescent mental health, stress reactivity needs to be analyzed through both the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis. Accordingly, this study examined how adolescents' internalizing and externalizing mental health symptoms are…

Several studies show altered heart rate variability (HRV) in autism spectrum disorder (ASD), but findings are neither universal nor specific to ASD. We apply a set of linear and nonlinear HRV measures--including phase rectified signal averaging--to segments of resting ECG data collected from school-age children with ASD, age-matched typically…

Phenylketonuria (PKU) is a rare, but serious, metabolic disease that can cause a variety of neurological, psychological, and academic complications. Fortunately, many individuals with PKU who are identified and treated early can go on to live a relatively normal life. However, PKU does continue to present with a variety of complex underlying…

This study investigated whether adolescent vagal stress reactivity to parent--adolescent conflict moderates the effects of family instability on the development of adolescent behavioral problems. Participants were 192 adolescents (M age = 12.4) and their parents across 2 measurement occasions. Results indicated that the interaction between family…

In collaborative learning situations, monitoring is needed to maintain common progress toward shared goals. The present study aimed to analyze group-level monitoring events, as well as groups' reactions to these events, to identify instances of adaptive regulation and maladaptive behavior. Three dimensions of monitoring events were qualitatively…

Individuals with autism may engage in problem behavior in order to escape aversive stimuli, including various noises. In this study, an 18-year-old young man with autism had a history of engaging in problem behavior to escape aversive noise that was typical to his everyday environment. By using biofeedback, in the form of heart rate measurement,…

The serine protease inhibitor neuroserpin regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin expression is particularly prominent at late stages of neuronal development in most regions of the central nervous system (CNS), whereas it is restricted to regions related to learning and memory in the…

There is little research on the functional assessment and treatment of anxiety and related problem behavior in children with autism spectrum disorder (ASD), particularly those with intellectual and developmental disability (IDD). In a recent study, we evaluated a multimethod strategy for assessing anxiety in children with ASD and IDD ("Am J…

This study examined children's morning hypothalamic-pituitary-adrenal (HPA) axis activation as a moderator of links between hostile, over-reactive parenting at age 4.5 years and children's skills for success in school (higher executive function and literacy and less externalizing behaviour) at age 6. Participants included 361 adoptive families.…

Several neurodevelopmental disorders are associated with preference for routine and challenging behavior following changes to routines. We examine individuals with Prader-Willi syndrome, who show elevated levels of this behavior, to better understand how previous experience of a routine can affect challenging behavior elicited by disruption to…

Background: Health literacy is crucial to develop health-related knowledge, adopt healthy lifestyles, and benefit from health care services. However, research on the association between health literacy and adolescent health outcomes, particularly on their prospective associations, is rare. We assessed health literacy using 3 validated measures,…

The present study examined the relationship between salivary cortisol and maternal responsiveness in mothers of boys with fragile X syndrome (FXS). Maternal responsivity is strongly associated with child outcomes, and children with FXS are at risk for compromised development due to intellectual disability and problem behavior. Increased…

Background: The hypothalamic-pituitary-adrenal (HPA) axis constitutes an important biological component of the stress response commonly studied through the measurement of cortisol. Limited research has examined HPA axis dysregulation in youth exposed to disasters. Objective: This study examined HPA axis activation in adolescent Hurricane Katrina…