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Direct linkMichael Borenstein – Research Synthesis Methods, 2024
In any meta-analysis, it is critically important to report the dispersion in effects as well as the mean effect. If an intervention has a moderate clinical impact "on average" we also need to know if the impact is moderate for all relevant populations, or if it varies from trivial in some to major in others. Or indeed, if the…
Descriptors: Meta Analysis, Error Patterns, Statistical Analysis, Intervention
Brinley N. Zabriskie; Nolan Cole; Jacob Baldauf; Craig Decker – Research Synthesis Methods, 2024
Meta-analyses have become the gold standard for synthesizing evidence from multiple clinical trials, and they are especially useful when outcomes are rare or adverse since individual trials often lack sufficient power to detect a treatment effect. However, when zero events are observed in one or both treatment arms in a trial, commonly used…
Descriptors: Meta Analysis, Error Correction, Computation, Simulation
Turner, Simon Lee; Korevaar, Elizabeth; Cumpston, Miranda S.; Kanukula, Raju; Forbes, Andrew B.; McKenzie, Joanne E. – Research Synthesis Methods, 2023
Interrupted time series (ITS) studies are frequently used to examine the impact of population-level interventions or exposures. Systematic reviews with meta-analyses including ITS designs may inform public health and policy decision-making. Re-analysis of ITS may be required for inclusion in meta-analysis. While publications of ITS rarely provide…
Descriptors: Quasiexperimental Design, Graphs, Accuracy, Computation
Stanley, T. D.; Doucouliagos, Hristos – Research Synthesis Methods, 2023
Partial correlation coefficients are often used as effect sizes in the meta-analysis and systematic review of multiple regression analysis research results. There are two well-known formulas for the variance and thereby for the standard error (SE) of partial correlation coefficients (PCC). One is considered the "correct" variance in the…
Descriptors: Correlation, Statistical Bias, Error Patterns, Error Correction
Doleman, Brett; Freeman, Suzanne C.; Lund, Jonathan N.; Williams, John P.; Sutton, Alex J. – Research Synthesis Methods, 2020
This study aimed to determine for continuous outcomes dependent on baseline risk, whether funnel plot asymmetry may be due to statistical artefact rather than publication bias and evaluate a novel test to resolve this. Firstly, we conducted assessment for publication bias in nine meta-analyses of postoperative analgesics (344 trials with 25 348…
Descriptors: Outcomes of Treatment, Risk, Publications, Bias
Wanner, Amanda; Baumann, Niki – Research Synthesis Methods, 2019
Background: Both PubMed and Ovid MEDLINE contain records from the MEDLINE database. However, there are subtle differences in content, functionality, and search syntax between the two. There are many instances in which researchers may wish to search both interfaces, such as when conducting supplementary searching for a systematic review to retrieve…
Descriptors: Search Strategies, Databases, Medical Research, Medical Evaluation
