Some patients benefit from a treatment while others may do so less or do not benefit at all. We have previously developed a two-stage network meta-regression prediction model that synthesized randomized trials and evaluates how treatment effects vary across patient characteristics. In this article, we extended this model to combine different…

Purpose: Individual-randomized trials are the gold standard for testing the efficacy and effectiveness of drugs, devices, and behavioral interventions. Health care delivery, educational, and programmatic interventions are often complex, involving multiple levels of change and measurement precluding individual randomization for testing.…

Background: Recent evidence suggests that pre-school children with co-occurring phonological speech sound disorder (SSD) and expressive language difficulties are at a higher risk of ongoing communication and literacy needs in comparison with children with these difficulties in isolation. However, to date there has been no systematic or scoping…

A habitually active environment is a feature of past times, and in stark contrast with that experienced by our children today. Consequently, twenty-first century physical education (PE) assumes a position of great responsibility. This is especially true in primary schools; a premise recently strongly supported by published evidence from the…

Background: Differing results regarding articulation skills in young children with cleft palate (CP) have been reported and often interpreted as a consequence of different surgical protocols. Aims: To assess the influence of different timing of hard palate closure in a two-stage procedure on articulation skills in 3-year-olds born with unilateral…

This study is a randomized controlled trial that assessed the impact of Early College High Schools on students' high school graduation, college enrollment, and college degree attainment, as well as students' high school experiences using extant data and survey data. The study included 10 Early Colleges that enrolled students in Grades 9 to 12 in…

This work summarizes the results of two randomized control trails (RCTs) aimed at evaluating the effectiveness of a professional development program for lower secondary school math teachers. The program, called M@t.abel, was financed by the Ministry of Education in Southern Italy with EU funds. It lasts a full school year and it is based on formal…

Findings from three years of a longitudinal randomized control trial involving a national U.S. sample of Algebra 1 teachers and students are reported. The study examines the effects of a connected classroom technology (CCT) professional development and classroom intervention on student achievement when compared to classroom instruction with…

Urban Alliance serves at-risk youth through its high school internship program, which provides training, mentoring, and work experience to high school seniors from distressed communities. The program aims to help youth move on to higher education or employment after graduation. The Urban Institute is conducting a six-year, randomized controlled…