NotesFAQContact Us
Collection
Advanced
Search Tips
Showing all 3 results Save | Export
Stakeholders' Experiences of Ethical Challenges in Cluster Randomized Trials in a Limited Resource Setting: A Qualitative Analysis
Peer reviewed Peer reviewed
Direct linkDirect link
Tiwonge K. Mtande; Carl Lombard; Gonasagrie Nair; Stuart Rennie – Research Ethics, 2024
Although the use of the cluster randomized trial (CRT) design to evaluate vaccines, public health interventions or health systems is increasing, the ethical issues posed by the design are not adequately addressed, especially in low- and middle-income country settings (LMICs). To help reveal ethical challenges, qualitative interviews were conducted…
Descriptors: Stakeholders, Ethics, Randomized Controlled Trials, Medical Research
COVID-19 Human Challenge Trials and Randomized Controlled Trials: Lessons for the Next Pandemic
Peer reviewed Peer reviewed
Direct linkDirect link
Charles Weijer – Research Ethics, 2024
The COVID-19 pandemic touched off an unprecedented search for vaccines and treatments. Without question, the development of vaccines to prevent COVID-19 was an enormous scientific accomplishment. Further, the RECOVERY and Solidarity trials identified effective treatments for COVID-19. But all was not success. The urgent need for COVID-19…
Descriptors: COVID-19, Pandemics, Immunization Programs, Research and Development
Ethical and Informative Trials: How the COVID-19 Experience Can Help to Improve Clinical Trial Design
Peer reviewed Peer reviewed
Direct linkDirect link
Emma Law; Isabel Smith – Research Ethics, 2024
During the COVID-19 pandemic, the race to find an effective vaccine or treatment saw an 'extraordinary number' of clinical trials being conducted. While there were some key success stories, not all trials produced results that informed patient care. There was a significant amount of waste in clinical research during the pandemic which is said to…
Descriptors: Ethics, Research Methodology, Integrity, COVID-19