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Direct linkSeo, Michael; Furukawa, Toshi A.; Karyotaki, Eirini; Efthimiou, Orestis – Research Synthesis Methods, 2023
Clinical prediction models are widely used in modern clinical practice. Such models are often developed using individual patient data (IPD) from a single study, but often there are IPD available from multiple studies. This allows using meta-analytical methods for developing prediction models, increasing power and precision. Different studies,…
Descriptors: Prediction, Models, Patients, Data Analysis
Miriam Hattle; Joie Ensor; Katie Scandrett; Marienke van Middelkoop; Danielle A. van der Windt; Melanie A. Holden; Richard D. Riley – Research Synthesis Methods, 2024
Individual participant data (IPD) meta-analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta-analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level, thus requiring statistical modelling of interactions between treatment effect and participant-level…
Descriptors: Meta Analysis, Randomized Controlled Trials, Outcomes of Treatment, Evaluation Methods
Belias, Michail; Rovers, Maroeska M.; Hoogland, Jeroen; Reitsma, Johannes B.; Debray, Thomas P. A.; IntHout, Joanna – Research Synthesis Methods, 2022
One of the main goals of an individual participant data meta-analysis (IPD-MA) of intervention studies is to investigate whether treatment effect differences are present, and how they are associated with patient characteristics. Examining treatment heterogeneity due to a continuous covariable (e.g., BMI or age) may be challenging, since there is…
Descriptors: Meta Analysis, Outcomes of Treatment, Prediction, Multivariate Analysis
Shih, Ming-Chieh; Tu, Yu-Kang – Research Synthesis Methods, 2021
Network meta-analysis (NMA) compares the efficacy and harm between several treatments by combining direct and indirect evidence. The validity of NMA requires that all available evidence form a coherent network. Failure to meet such requirement is known as inconsistency. The most popular approach to inconsistency detection is to compare the direct…
Descriptors: Networks, Meta Analysis, Evidence, Evaluation Methods
Cerullo, Enzo; Jones, Hayley E.; Carter, Olivia; Quinn, Terry J.; Cooper, Nicola J.; Sutton, Alex J. – Research Synthesis Methods, 2022
Standard methods for the meta-analysis of medical tests, without assuming a gold standard, are limited to dichotomous data. Multivariate probit models are used to analyse correlated dichotomous data, and can be extended to model ordinal data. Within the context of an imperfect gold standard, they have previously been used for the analysis of…
Descriptors: Meta Analysis, Test Format, Medicine, Standards
Godolphin, Peter J.; White, Ian R.; Tierney, Jayne F.; Fisher, David J. – Research Synthesis Methods, 2023
Estimation of within-trial interactions in meta-analysis is crucial for reliable assessment of how treatment effects vary across participant subgroups. However, current methods have various limitations. Patients, clinicians and policy-makers need reliable estimates of treatment effects within specific covariate subgroups, on relative and absolute…
Descriptors: Meta Analysis, Outcomes of Treatment, Medical Research, Comparative Analysis
