Meta-analysis of proportions is conceptually simple: Faced with a binary outcome in multiple studies, we seek inference on some overall proportion of successes/failures. Under common effect models, exact inference has long been available, but is not when we more realistically allow for heterogeneity of the proportions. Instead a wide range of…

Meta-regression analyses usually focus on estimating and testing differences in average effect sizes between individual levels of each meta-regression covariate in turn. These metrics are useful but have limitations: they consider each covariate individually, rather than in combination, and they characterize only the mean of a potentially…

Tolerance intervals provide a bracket intended to contain a percentage (e.g., 80%) of a population distribution given sample estimates of the mean and variance. In random-effects meta-analysis, tolerance intervals should contain researcher-specified proportions of underlying population effect sizes. Using Monte Carlo simulation, we investigated…

Context: A perennial problem in applied statistics is the inability to justify strong claims about cause-and-effect relationships without full knowledge of the mechanism determining selection into treatment. Few research designs other than the well-implemented random assignment study meet this requirement. Researchers have proposed partial…

Bayesian methods seem a natural choice for combining sources of evidence in meta-analyses. However, in practice, their sensitivity to the choice of prior distribution is much less attractive, particularly for parameters describing heterogeneity. A recent non-Bayesian approach to fixed-effects meta-analysis provides novel ways to think about…

Background: Meta-analysis is considered to be the gold standard for evidence synthesis. It involves combining data from multiple independent sources to produce a summary estimate with improved precision. Traditionally, meta-analysis methods have been applied to a large collection of studies, and past research efforts have indicated its numerous…

There exists a variety of interval estimators for the overall treatment effect in a random-effects meta-analysis. A recent literature review summarizing existing methods suggested that in most situations, the Hartung-Knapp/Sidik-Jonkman (HKSJ) method was preferable. However, a quantitative comparison of those methods in a common simulation study…

It is common to include multiple dependent variables (DVs) in single-case experimental design (SCED) meta-analyses. However, statistical issues associated with multiple DVs in the multilevel modeling approach (i.e., possible dependency of error, heterogeneous treatment effects, and heterogeneous error structures) have not been fully investigated.…

It is now widely accepted that the standard inferential toolkit used by the scientific research community--null-hypothesis significance testing (NHST)--is not fit for purpose. Yet despite the threat posed to the scientific enterprise, there is no agreement concerning alternative approaches for evidence assessment. This lack of consensus reflects…