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Gerald Gartlehner; Leila Kahwati; Rainer Hilscher; Ian Thomas; Shannon Kugley; Karen Crotty; Meera Viswanathan; Barbara Nussbaumer-Streit; Graham Booth; Nathaniel Erskine; Amanda Konet; Robert Chew – Research Synthesis Methods, 2024
Data extraction is a crucial, yet labor-intensive and error-prone part of evidence synthesis. To date, efforts to harness machine learning for enhancing efficiency of the data extraction process have fallen short of achieving sufficient accuracy and usability. With the release of large language models (LLMs), new possibilities have emerged to…
Descriptors: Data Collection, Evidence, Synthesis, Language Processing
Fangxing Bai; Ben Kelcey; Amota Ataneka; Yanli Xie; Kyle Cox; Nianbo Dong – Society for Research on Educational Effectiveness, 2024
Purpose: Multisite mediation studies are a cornerstone in mapping out developmental processes because they probe the mechanisms of a treatment while creating key opportunities to learn from and about variation in those mechanisms across sites. Despite the prevalence of multisite studies, a significant gap in the literature is how to plan such…
Descriptors: Randomized Controlled Trials, Mediation Theory, Statistical Analysis, Robustness (Statistics)
Kylie E. Hunter; Mason Aberoumand; Sol Libesman; James X. Sotiropoulos; Jonathan G. Williams; Jannik Aagerup; Rui Wang; Ben W. Mol; Wentao Li; Angie Barba; Nipun Shrestha; Angela C. Webster; Anna Lene Seidler – Research Synthesis Methods, 2024
Increasing concerns about the trustworthiness of research have prompted calls to scrutinise studies' Individual Participant Data (IPD), but guidance on how to do this was lacking. To address this, we developed the IPD Integrity Tool to screen randomised controlled trials (RCTs) for integrity issues. Development of the tool involved a literature…
Descriptors: Integrity, Randomized Controlled Trials, Participant Characteristics, Computer Software
Wendy Castillo; Lindsay Dusard – Society for Research on Educational Effectiveness, 2024
Background: The emergence of causal research in education was almost strictly quantitative twenty years ago, however, that landscape has changed considerably. The number of intervention studies fielded and completed annually has increased substantially, and the quality of the evaluations is much more robust, including paying much greater attention…
Descriptors: Randomized Controlled Trials, Educational Research, Equal Education, Educational Policy
A. E. Ades; Nicky J. Welton; Sofia Dias; David M. Phillippo; Deborah M. Caldwell – Research Synthesis Methods, 2024
Network meta-analysis (NMA) is an extension of pairwise meta-analysis (PMA) which combines evidence from trials on multiple treatments in connected networks. NMA delivers internally consistent estimates of relative treatment efficacy, needed for rational decision making. Over its first 20 years NMA's use has grown exponentially, with applications…
Descriptors: Network Analysis, Meta Analysis, Medicine, Clinical Experience
Konstantina Chalkou; Tasnim Hamza; Pascal Benkert; Jens Kuhle; Chiara Zecca; Gabrielle Simoneau; Fabio Pellegrini; Andrea Manca; Matthias Egger; Georgia Salanti – Research Synthesis Methods, 2024
Some patients benefit from a treatment while others may do so less or do not benefit at all. We have previously developed a two-stage network meta-regression prediction model that synthesized randomized trials and evaluates how treatment effects vary across patient characteristics. In this article, we extended this model to combine different…
Descriptors: Medical Research, Outcomes of Treatment, Risk, Randomized Controlled Trials
Douglas D. Ready; Sierra G. McCormick; Rebecca J. Shmoys – Annenberg Institute for School Reform at Brown University, 2024
This paper describes a 12-week cluster randomized controlled trial that examined the efficacy of BookNook, a virtual tutoring platform focused on reading. Cohorts of first- through fourth-grade students attending six Rocketship public charter schools in Northern California were randomly assigned within grades to receive BookNook. Intent-to-Treat…
Descriptors: Computer Assisted Instruction, Instructional Effectiveness, Tutoring, Reading Achievement