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Stakeholders' Experiences of Ethical Challenges in Cluster Randomized Trials in a Limited Resource Setting: A Qualitative Analysis
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Tiwonge K. Mtande; Carl Lombard; Gonasagrie Nair; Stuart Rennie – Research Ethics, 2024
Although the use of the cluster randomized trial (CRT) design to evaluate vaccines, public health interventions or health systems is increasing, the ethical issues posed by the design are not adequately addressed, especially in low- and middle-income country settings (LMICs). To help reveal ethical challenges, qualitative interviews were conducted…
Descriptors: Stakeholders, Ethics, Randomized Controlled Trials, Medical Research
COVID-19 Human Challenge Trials and Randomized Controlled Trials: Lessons for the Next Pandemic
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Charles Weijer – Research Ethics, 2024
The COVID-19 pandemic touched off an unprecedented search for vaccines and treatments. Without question, the development of vaccines to prevent COVID-19 was an enormous scientific accomplishment. Further, the RECOVERY and Solidarity trials identified effective treatments for COVID-19. But all was not success. The urgent need for COVID-19…
Descriptors: COVID-19, Pandemics, Immunization Programs, Research and Development