Background: ADHD is a generally persistent neurodevelopmental condition that can have significant consequences if left untreated, and medication, often in conjunction with psychotherapy, is the first-line treatment with well-established efficacy. Adolescents and young adults (AYAs) represent a particularly vulnerable and understudied subgroup and…

Purpose: Adolescents and adults with Down syndrome are noted to display symptoms and behaviors consistent with a diagnosis of Obsessive Compulsive Disorder. While evidenced-based interventions, including psychopharmacology and therapeutic interventions including exposure and response prevention, exist and effectively treat obsessive-compulsive…

Background: Hypertension (HTN) is a serious medical disease and the main cause of cardiovascular diseases and premature death worldwide. Purpose: The purpose of this study was to investigate the effectiveness of online mindfulness-based stress reduction (OMBSR) on systolic blood pressure (BP), diastolic blood pressure (BP), and heart rate (HR) in…

Purpose: Previous studies have demonstrated that physical exercise can modulate the endogenous melatonin level in children with autism spectrum disorder (ASD) and improve their sleep quality. However, it remains unclear whether physical exercise or melatonin supplement, or a combination of both, is more effective in improving sleep quality in this…

Introduction: Depression impacts many individuals with autism spectrum disorder (ASD), carrying increased risk of functional impairment, hospitalization, and suicide. Prescribing medication to target depression in patients with ASD occurs despite limited available systematic data describing medication management of depression in this population.…

The objective of this meta-epidemiological study was to explore the impact of attrition rates on treatment effect estimates in randomised trials of chronic inflammatory diseases (CID) treated with biological and targeted synthetic disease-modifying drugs. We sampled trials from Cochrane reviews. Attrition rates and primary endpoint results were…

Limited data exist on educational programs for people using insulin pump (IP) therapy or those considering its initiation, and the influence of individual characteristics on their educational pathway remains unclear. Our aim was to analyze the characteristics of people with type 1 diabetes (T1D) referred for IP therapy and how these…

Purpose: School teachers show higher levels of internalized distress compared to those in many other professions. In two exploratory studies, we examine the relative and interactive impacts of mindfulness training (MT) and medication use on reductions in depressive and anxious symptoms in teachers over time. Design/Approach/Methods: These…

Introduction: Executive function (EF) deficits are common in youth with ADHD and pose significant functional impairments. The extent and effect of interventions addressing EF in youth with ADHD remain unclear. Methods: We conducted a systematic literature review using PRISMA guidelines. Included studies were randomized controlled trials of…

Several meta-analyses have demonstrated that bullying prevention programs are successful in reducing bullying. However, scant research addresses if and how such anti-bullying efforts affect long-term internalizing health problems and even less on later use of pharmacotherapy and psychotherapy. This study explores how the school-based Olweus…

Objective: Stimulant medications are the main treatment for Attention Deficit Hyperactivity Disorder (ADHD), but overall treatment efficacy in adults has less than a 60% response rate. This study aimed to identify neural and cognitive markers predictive of longitudinal improvement in response to stimulant treatment in drug-naïve adults with ADHD.…

Background: This study aimed to establish the effectiveness of a hypertension knowledge education intervention among Indian adolescents to foster lifestyle changes aimed at preventing hypertension. Methods: The Hypertension Knowledge Test (HKT) was used to assess changes in knowledge using a repeated-measures one-way analysis of variance (ANOVA).…

Elective genetic testing (EGT) programs that provide pharmacogenomic information to guide medication management and screen for medically actionable disease predispositions are emerging in a number of health systems. Primary care providers (PCPs) are at the forefront of test initiation, patient education, and management of EGT results. However,…

Background: Challenging behaviours are common among children and adolescents with intellectual disabilities. Such behaviours often result in poor quality of life outcomes such as physical injury, difficulties with relationships and community integration. Aim: This systematic review aimed to synthesise evidence from studies that assessed the effect…

This study aims to examine the moderating role of individual (sex, symptom severity, and comorbid disorders) and familial (parental stress and parental depressive symptoms) factors on the improvement of organization, time management, and planning (OTMP) skills of youths with attention-deficit hyperactivity disorder (ADHD) following participation…