This research explored the perception towards chemistry of class ten students of Phuentsholing Higher Secondary School in Bhutan. It was also to find out the factors that influenced the perception of students towards chemistry. For this research, 90 students were chosen as sample from a population of 95 students through convenience sampling technique to maintain 95% confidence level and 0.025 margin of error. Cronbach's alpha was calculated to be 0.89 during reliability test. A survey questionnaire comprised of 41 items categorized as classroom environment, teaching pedagogy, resources, students' level of interest, and curriculum was used to collect data. A descriptive analysis was done using excel/SPSS. The study concluded that chemistry is the least favourite subject of the students known through survey questionnaire. The classroom environment in the school is found to be conducive and interactive. It was found that chemistry teachers used different teaching strategies but less practical work. The study found that students learned more through practical work. It was known that students don't find chemistry practical fun and enjoyable. The findings also indicated that not much multimedia was used in teaching. Besides, the study revealed that students see chemistry subjects containing more abstract ideas and chemical formulas which make learning difficult. Surprisingly, only 30% (27) students were willing to take up jobs that require knowledge of chemistry.