This study examined the mediating roles of psychological resilience and hope in the relationship between school burnout, and the well-being of students. Participants consisted of 721 Turkish secondary school students, (52.6% girls; mean age = 12.76 ± 0.82) studying from grades 5 to 8. The participants completed the School Burnout Inventory, Children's Hope Scale, Child and Youth Resilience Measure, and Stirling Children's Well-Being Scale. The results showed that school burnout was negatively related to resilience, hope, and well-being. Resilience and hope were positively associated with well-being. The results of structural equation modeling revealed that resilience and hope mediated the impact of school burnout on well-being. These results emphasize the potential of resilience and hope as key factors in enhancing well-being among secondary school students. They also provide a foundation for developing targeted interventions to foster well-being within the school context by promoting strength-based strategies and practices, including cultivating resilience and hope.