The purpose of this study is to reveal the relationship between 21st century learning skills and educational technology competencies of secondary school students. The population of this correlational research consists of 37.904 secondary school students in central districts (Ipekyolu, Tusba, and Edremit) of Van province. This study was carried out with 920 secondary school students determined by stratified sampling method. As data collection tools, "21st Century Learning Skills Scale" and "Educational Technology Standards Scale" were used. Pearson Product Moment Correlation Coefficient and simple linear regression analysis were used in the analysis of research data. As a result of the study, it was concluded that there is a moderate, positive and significant relationship between students' 21st century learning skills and educational technology competencies. In addition, it was determined that students' educational technology competencies are a significant predictor of their 21st century learning skills and can explain approximately one quarter (25.1%) of their 21st century learning skills. In teacher education and in-service training programs, teachers should be well-educated in that they can contribute to the students' development of 21st century and technological skills.