The authors describe Hexacago Health Academy (HHA) 2.0, a five-year summer intervention designed to increase interest in science, technology, engineering, and mathematics (STEM) among mostly Black high school students in Chicago. The program features public health fundamentals and game design using principles of systems thinking, social-cognitive career theory, experiential learning, playing and making, and storytelling. They conclude that game play and game making can facilitate community collaborations and encourage marginalized youth to engage in complex systems thinking.