Background/purpose: One of the skills that students had to master in science learning was science process skills. However, there has not been much research examining these skills in elementary schools, especially those related to practicum guides integrated with local wisdom. Therefore, this study aimed to analyze the effectiveness of a science practicum guide for elementary schools integrated with Catur Pramana to improve students' science process skills. This guide was developed based on the surrounding environment and the concept of local wisdom in Bali, Indonesia. Materials/methods: This study used a quasi-experimental approach with a one-group pre-test and post-test design involving 94 students as samples. Data were collected through practicum observation sheets and analyzed using gain scores to assess the improvement of students' science process skills. Results: The analysis's results showed that the practicum guide was effective in improving science process skills, which were included in the moderate category. Furthermore, each indicator of science process skills showed an increase, with each gain score also included in the moderate category. Among the six indicators measured, the prediction indicator had the lowest score compared to the other indicators. Conclusion: The elementary school science practicum guide integrated with Catur Pramana proved effective in improving students' science process skills. Therefore, this guide was seen as an effective solution to help students develop science process skills in elementary schools. This study also recommended the use of similar guides at higher school levels.