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Direct linkHoffman, Janlyn R.; Brandwein, Nathan J.; Nguyen, Peter V. – Learning & Memory, 2019
Beta-adrenergic receptors ([beta]-ARs) prime hippocampal synapses to stabilize long-term potentiation (LTP). This "metaplasticity" can persist for 1-2 h after pharmacologic activation of [beta]-ARs. It requires activation of PKA (cAMP-dependent protein kinase) during [beta]-AR priming. A-kinase anchoring proteins (AKAPs) tether PKA to…
Descriptors: Animals, Science Experiments, Foreign Countries, Stimulation
Sekeres, Melanie J.; Moscovitch, Morris; Grady, Cheryl L.; Sullens, D. Gregory; Winocur, Gordon – Learning & Memory, 2020
Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alters retrieval-induced activity in the hippocampus and anterior cingulate cortex (aCC) relative to a…
Descriptors: Memory, Animals, Brain Hemisphere Functions, Conditioning
