This protocol guides the review of research that informs What Works Clearinghouse (WWC) intervention reports in the Supporting Postsecondary Success topic area. The protocol is used in conjunction with the WWC Procedures and Standards Handbooks (version 4.0). This protocol focuses broadly on academic and nonacademic interventions that aim to support postsecondary success, including first year experience courses, credit recovery programs, linked learning communities, residential learning communities, interventions focused on financial aid, and student counseling and mentoring interventions. Systematic reviews of evidence in this topic area address the following research questions: (1) Which interventions are effective at helping students improve access and enrollment in college?; (2) Which interventions are effective at helping students increase credit accumulation and persistence in college?; (3) Which interventions are effective at helping students improve academic achievement?; (4) Which interventions are effective at helping students complete college?; (5) Which interventions are effective at helping students improve their prospects in the labor market?; and (6) Is the reviewed intervention more or less effective for certain subgroups of students (including first-generation college students, women, racial/ethnic minorities, academically underprepared students, students from low socioeconomic status backgrounds (e.g., Pell Grant recipients), and/or community college students)?