International scientific mobility and research careers are two concepts that are intimately related. Yet, it has been very difficult for scholarship to pinpoint exactly how international mobility impacts on research careers. This paper contributes to this question by investigating links between international mobility, research career stage progression and job changes. It does so using a large-scale survey (MORE) which targets researchers based in European universities. The results establish that the profile of international mobility varies by academic research career stage. They also show that for researchers in the established mid-career phase who are working internationally, there are career advancement benefits associated with return mobility to their home country. However, these benefits may reduce if the timing of return is too delayed. The paper concludes by discussing the implications of these results for researcher mobility policy in the context of the European Higher Education Area and the European Research Area.