The present study aimed to investigate the relationship between self-actualization (SA) and speaking skill, creativity (C) and speaking skill, and also the interaction of both creativity and self-actualization and speaking skill to find out which of the two variables of SA or C can better predict speaking skill of the intermediate EFL learners. In so doing, after homogenizing the students as Intermediate ones via an Oxford Placement Test (OPT), two questionnaires of SA (Jones & Crandall, 1986) and Creativity (Torrence, 1990) were administered to 72 intermediate students. Having administered the questionnaires, the researcher required the subjects to deliver a lecture on general and controversial topics. The data collected from the questionnaires as well as the scores given to their speaking skill were analyzed through SPSS (21.00). Results indicated that there was statistically significant relationship between SA and speaking skill and between C and speaking skill. Results also indicated that both variables of SA and C can meaningfully predict intermediate English as a Foreign Language (EFL) learners' speaking skill; however, C was a better predictor of speaking skill. The findings of the present study demonstrated that more concentration is needed to be placed on these two psychological factors in order to enhance students' speaking performances.