Background: Researchers studying siblings of people with an autism spectrum disorder (ASD) suggest that growing up with an individual with disability has positive and negative effects. Method: Qualitative content analysis of semistructured interviews with 14 typically developing (TD) adolescents with a brother with an ASD and their mothers was used to explore the experience of growing up with a sibling with an ASD and identify differences in the relationship with, and attitude toward, the brother. Results: TD siblings expressed mixed feelings about their brother, a precocious sense of responsibility, concern about the future, friendship difficulties, and troubles and the desire to talk about their experience. Most adolescents integrated their positive and negative feelings; however, 3 adolescents displayed rejection, denial, or a sense of persecution. Conclusions: Qualitative research into the experiences of adolescent siblings of people with an ASD should be used to develop support programs to help adolescents manage their relationship with a sibling with a disability.