What goes into teaching a tissue engineering course in a chemical engineering or bioengineering department? Developing any new course presents numerous challenges such as topics to cover, textbook selection, and types of assignments to give. Additionally, in an area such as tissue engineering where the technology is constantly evolving, the course must stay current on cutting-edge research. With the increasing demand for improved healthcare, bio-focused fields such as tissue engineering have gathered increased attention. The authors surveyed 80 universities across the country, and found that at least 40 universities currently offer a course in tissue engineering. Of the 20 universities that comprise the top-10 lists of chemical engineering and bioengineering graduate programs from the 2006 US News & World Report survey, 16 currently offer a tissue engineering course. Many courses are offered by the chemical engineering department, although most are taught in the growing number of bioengineering/biomedical engineering departments across the country. This article, containing examples and insights from the authors' experiences teaching tissue engineering at the University of Kansas and the University of Michigan-Ann Arbor, aims to serve as a guide both to those developing a new course in tissue engineering and those looking for ideas to supplement an existing tissue engineering course. This article discusses key administrative details, such as textbook selection, class level, prerequisites, and types of assignments and exams, as well as course curricula. The article also offers suggestions for incorporating quantitative material into the course.