In this research, Entrepreneurship and STEM (Science, Technology, Engineering, Mathematics) activity has been established to the gifted secondary school students and to show their applicability. Entrepreneurship and STEM will be shortened as E-STEM. The activity of Colors was implemented at Inönü University Scientific and Technological Research Center (ISTRC) Laboratories and Inönü University Faculty of Fine Arts with gifted secondary school students. In the study, 14 gifted secondary school students were trained for a week based on the ESTEM approach. The students generated solutions to the problem statuses that were given to them using the components of science, technology, mathematics, engineering and entrepreneurship for a week. They developed products with a higher added-value by combining their imagination and creativity, and implemented studies to commercialize their products. The students designed their prototypes in three groups and then developed their designs by examining the dimensions of art and marketing. When examining the answers given by the students to open-ended questions in the activity evaluation form, it was determined that they thought that the E-STEM oriented activity developed their knowledge and skills in the areas of science, technology, mathematics, engineering, entrepreneurship and art.