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5HTT Genotype Moderates the Influence of Early Institutional Deprivation on Emotional Problems in Adolescence: Evidence from the English and Romanian Adoptee (ERA) Study
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Kumsta, Robert; Stevens, Suzanne; Brookes, Keeley; Schlotz, Wolff; Castle, Jenny; Beckett, Celia; Kreppner, Jana; Rutter, Michael; Sonuga-Barke, Edmund – Journal of Child Psychology and Psychiatry, 2010
Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to…
Descriptors: Stress Variables, Emotional Problems, Psychopathology, Adoption
Amygdala, Hippocampal and Corpus Callosum Size Following Severe Early Institutional Deprivation: The English and Romanian Adoptees Study Pilot
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Mehta, Mitul A.; Golembo, Nicole I.; Nosarti, Chiara; Colvert, Emma; Mota, Ashley; Williams, Steven C. R.; Rutter, Michael; Sonuga-Barke, Edmund J. S. – Journal of Child Psychology and Psychiatry, 2009
The adoption into the UK of children who have been reared in severely deprived conditions provides an opportunity to study possible association between very early negative experiences and subsequent brain development. This cross-sectional study was a pilot for a planned larger study quantifying the effects of early deprivation on later brain…
Descriptors: Disadvantaged, Foreign Countries, Brain, Cognitive Processes