This report contains a synthesis of key themes and issues discussed within each question posed to panel members at a roundtable on the changing Canadian research landscape. The keynote address, "Knowledge, Innovation and International Cooperation: The Sisyphus Challenge," by Francisco Sagasti, is presented in its entirety. Canadian researchers involved in research in the South find that the uncertainty of the policy environment and the instability in resource availability often disrupt research and development initiatives. The report then summarizes the conversations in panel sessions: (1) "The Opportunity and the challenges of North-South Collaboration"; (2) "Operational Issues"; and (3) "Outside Perspectives." Among the ideas and issues that emerged were the concept of"research diplomacy" as a potential new dimension of Canadian foreign policy. It must be recognized at the national policy level and at individual Canadian universities that Canada's national interest is served through collaboration with Southern researchers. Any approach for increased collaboration must recognize the complexity and heterogeneity of Southern partners in terms of research capacity, strengths, and development needs. Three appendixes contain background information, a summary of campus-level roundtables on the internationalization of Canadian research, and a list of roundtable participants. (SLD)