The dissertation is composed of two sections. The first section is composed of chapters one, two, and three and describes the study of macrocyclic [beta]-hairpin peptides derived from [beta]-sheet peptides. The second section is composed of chapters four and five and discusses the curricular innovations made to support the remote instruction of an…

High school students' chemistry self-efficacy (CSE) and scientific identity (SI) are not well understood in the high school chemistry classroom. The purpose of this research was to quantitatively investigate the interaction between gender and giftedness on students' CSE and SI in a suburban high school chemistry classroom, with and without…

The 21st century technology has advanced to become an accessible beacon of education. The physical boundaries of the chemistry laboratory have expanded with the use of innovative virtual lab simulations despite disparate results from previous investigations of student performance comparing virtual lab simulations with traditional laboratory…

Future college environments, including those in chemistry, will entail flexible formats. The pandemic spurred appreciation of the need, and though it has largely passed, adaptability to multiple formats in the future has been a critical part of planning for a rapidly changing future. Experiences during the pandemic will guide pedagogical changes…

The gap between the number of available STEM workers and employers' needs in the workforce is projected to be about two million by 2025. One way to reduce the magnitude of this gap is to increase the number of entry-level STEM workers joining the workforce, however the attrition rate for college STEM majors is about 33%. Research has indicated…

Ambient ionization mass spectrometry enables rapid in-situ analysis of a plethora of analytes that are relevant to the forensic and defense communities. As the arsenal of ambient ionization techniques, aimed at solving specific targeted problems, continues to expand, the adoption of these techniques into non-academic settings has been relatively…

This study investigates the challenge faced by eighth-grade students at Southern State Middle School in grasping abstract concepts within the domains of physical science, physics, and chemistry. This difficulty is manifested in their poor performance on summative assessments. A comprehensive analysis of state-provided data, in conjunction with…

The manuscripts in this dissertation enhance the research on the psychology of the undergraduate student experience in laboratory courses, those that typify collaborative practical work. For science and engineering fields in higher education, persistence of students who identify as female and/or as a member of an underrepresented ethnic minority…

There is consensus in the literature that peer learning is beneficial for student content learning as well as affective response to courses. Peer learning methods are used frequently in large science and math courses and often show positive outcomes from all participants. Peer learning programs in undergraduate science education rarely distinguish…

Nanostructures of organosilanes, thin metal films, and protein nanopatterns were prepared and analyzed with atomic force microscopy (AFM). Organosilanes with designed functional groups were used to selectively pattern green fluorescent protein at the nanoscale using protocols developed with particle lithography. Mesospheres are deposited onto a…

Laboratory courses have been the focus of much research and debate in the field of chemistry. One goal for the laboratory that is consistently cited by faculty is student learning of hands-on skills. Despite this, hands-on skills are rarely assessed in practice because to do so is resource intensive. Digital badges allow each individual student to…

The purpose of this study was to understand if a green chemistry laboratory design facilitated students' transformative experiences in a first-semester general chemistry course for science majors. The study population consisted of 18 college students enrolled in the course at a small, rural, mid-Atlantic university. Traditional chemistry…

Recently, there have been many calls for an increase in instruction on the nature of science (NOS) in schools (i.e. NRC, 1996; NGSS Lead States, 2013). These calls recognize the importance of this topic at all levels of science education, but there is little guidance in terms of how to address it effectively in curricula. Similarly, there have…

Freshman science courses are intended to prepare students for the rigor and expectations of subsequent college science. While secondary education aims to prepare students for the college curriculum, many incoming freshman lack the sense of responsibility for their own learning that is essential for success in a college-level course. The freshman…

In the science, technology, engineering, and mathematics (STEM) disciplines the laboratory has been the major component for understanding theoretical knowledge. The laboratory is the workplace for scientific research where students develop scientific thinking, conduct scientific investigations, and acquire knowledge of physical principles and…