Two-way telephone conferences were developed to make continuing medical education conveniently available to health professionals in community hospitals. This manual describes: (1) the development of such conferences at the University of Missouri; (2) guidelines for both contributing faculty and receiving institutions in regard to format of primary and supporting presentation materials; (3) suggestions for moderators at the studio; (4) general instructions for receiving institutions (e.g., equipment and facilities needed, materials to be received, materials organization); and (5) program procedures for receiving institutions. (DAG)